Uncontrolled growth of cells in squamous cell carcinoma, the second most common form of skin cancer. Squamous-cell carcinoma or squamous-cell cancer (SCC or SqCC) is a cancer of a kind of epithelial cell, the squamous cell. SCC is a histologically distinct form of cancer. It arises from the uncontrolled multiplication of cells of epithelium, or cells showing particular cytological or tissue architectural characteristics of squamous-cell differentiation, such as the presence of keratin, tonofilament bundles, or desmosomes, structures involved in cell-to-cell adhesion.